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Cardalis Chewable Tablets

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IB# 107023
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Prescription Item

Cardalis Chewable Tablets
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Cardalis Chewable Tablets are a unique tablet combining benazepril and spironolactone for dogs suffering from heart failure. This combination of two active ingredients, in a single easy-to-administer daily tablet can improve compliance.

Benazepril is in a class of drugs called ACE inhibitors, it dilates the veins and helps to decrease fluid retention. This medication may be used to treat high blood pressure, as a vasodilator in the treatment of heart failure and as adjunct treatment of chronic kidney failure. High blood pressure makes the heart work harder. If this continues, the heart and arteries may get damaged and not function correctly. If the heart does not work properly, it could also damage the blood vessels of the brain, heart, and kidneys.

Spironolactone is a diuretic that removes excess fluid from the body by increasing the flow of urine.  It is used to treat congestive heart failure and ascites (fluid in the abdomen).




  • Combination of an Angiotensin Converting Enzyme inhibitor (ACEi) with an Aldosterone receptor blocker has been proven to be better than an ACEi along to counteract the effects of degnerative heart conditions
  • Single small flavored tablet for improved compliance

Active Ingredients

Benazepril HCL, Spironolactone

Side Effects

Side effects may include stomach upset, lack of appetite, vomiting, diarrhea. Notify your veterinarian if vomiting or diarrhea persists or is severe. Notify your veterinarian if your pet is extremely tired or appears dizzy (uncoordinated).

Other side effects may occur. If you notice anything unusual, contact your veterinarian.


Cardalis should be given orally as directed by your veterinarian. Cardalis should be administered with food. Do not stop giving this medication without your veterinarian's approval.


Do not use in animals sensitive to ACE inhibitors or spironolactone. Do not use in conjunction with non-steroidal anti-inflammatory drugs in dogs with renal insufficiency. Do not administer to dogs with Addison's Disease, hyperkalemia, or hyponatremia.

Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, and a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. The following drugs can potentially interact with benazepril HCl: digoxin, non-steroidal anti-inflammatory agents (e.g. carprofen, metacam), diuretics (e.g. furosemide), potassium supplements and other vasodilators. The following drugs can potentially interact with spironolactone: Digoxin, mitotane, neuromuscular blockers, triamterene, potassium supplements, or salicylates. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.

Adverse Reactions

If you are concerned that your pet has experienced an adverse reaction to this medication or have concerns about the product, please contact the manufacturer, Ceva, at 800-999-0297 or contact Vetsource customer service at 877-738-4443.


Store at controlled room temperature (68-77 degrees F), in original container. Excursions permitted between 59-86 degrees F.

IB# 107023
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