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Advantage Multi Topical Solution for Dogs (imidacloprid + moxidectin)

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IB# 107062
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Prescription Item

Advantage Multi Topical Solution for Dogs (imidacloprid + moxidectin)
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Advantage Multi Topical Solution is a broad-spectrum once a month topical application that prevents heartworm disease and treats heartworm microfilaria, kills fleas, treats and controls hookworms, roundworms, whipworms, and treats sarcoptic mange in dogs. 


Dogs (at least 7 weeks of age and weighing at least 3 lbs) 

Product Description

Advantage Multi Topical Solution is a colorless to yellow liquid.


  • Once a month application that works systemically to prevent heartworm disease
  • Shampooing 90 minutes after treatment does not reduce the effectiveness in the prevention of heartworm disease
  • Shampooing or water immersion 4 days after treatment will not reduce the effectiveness in the treatment of fleas. However, shampooing as often as once weekly may reduce the effectiveness of the product agains fleas.
  • Kills fleas and prevents flea infestations (C. felis) when given routinely every 30 days
  • Treats and controls hookworms (A. caninum, U. stenocephala), roundworms (T. canis, T. leonina), whipworms (T. vulpis), and sarcoptic mange when given routinely every 30 days
  • Approved for dogs 7+ weeks of age, weighing more than 3 lbs

Active Ingredients

imidacloprid, moxidectin



Advantage Multi Topical Solution should be applied as directed by your veterinarian. This medication should be administered at every 30 day intervals, year-round to guarantee complete protection.  For dogs over 110 lbs, use the appropriate combination of tubes to ensure complete protection.

Immediately before use, open the pouch and remove the tube. Hold the tube at the crimped end with the cap in the upright position (tip up). Remove the cap from the tube and turn the cap over and push the other end of the cap onto the tip of the tube.  Twist the cap to break the seal then remove the cap from the tube. Always keep the tube in the upright position to prevent leaking.

With the dog standing with its back horizontal, part the fur at the administration site (between the shoulder blades) until the skin is visible.  Place the tube vertically against the skin between the shoulder blades of the dog. Squeeze the tube and gently apply the solution in one or more spots (depending on weight of dog) starting between the top of the backline from the base of the neck to the upper back and shoulder blades, apply in areas that are inaccessible to licking.  Avoid applying an excessive amount of solution in any one spot which may cause some to run or drip off the dog.

Do not contact or allow children to contact the application site until dry.  Wash hands and contacted skin thoroughly with soap and water immediately after application.

Missed Doses

Give the dose as soon as you remember, unless it is time for the next dose.  Do not double dose.  If your dog has missed a dose please consult with your veterinarian.


Side Effects

Advantage Multi Topical Solution is generally well tolerated in dogs when given at the usual dose.  Stiff hair, a damp appearance of the hair, or a powdery residue may be observed at the application site. There are very few side effects when the drug is given a the usual dose.  The following side effects have been reported with the use of Advantage Multi Topical Solution: temporary hairloss and slight inflammation or scabs at or near the application site, vomiting, diarrhea, decreased appetite, lethargy, and itchiness. 

Ensure that the dog does not ingest the product. Ingestion of this product may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors.

Other side effects may occur. If you notice anything unusual, contact your veterinarian.



For topical use only. Avoid oral ingestion. For the first 30 minutes after application ensure the dog cannot lick the product from the application sites on themselves or other treated animals.  Children should not come in contact with the application site for 2 hours after application.  Product is highly flammable. Keep away from heat, sparks, open flame, or other sources of ignition. Avoid contact with eyes, skin, and clothing.


Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.

Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.

Adverse Reactions

If you are concerned that your pet has experienced an adverse reaction to this medication or have concerns about the product, please contact the manufacturer, Bayer, at 800-422-9874 or contact Vetsource customer service at 877-738-4443.


Store long term between 39-77 degrees F.  Store in original packaging to protect from moisture. Keep out of reach of children and pets.

IB# 107062
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